TY - JOUR
T1 - Metabolism of highly persistent PCB congener, 2,4,5,2′,4′,5′-hexachlorobiphenyl, by human CYP2B6
AU - Ariyoshi, N.
AU - Oguri, K.
AU - Koga, N.
AU - Yoshimura, H.
AU - Funae, Y.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2′,4′,5′-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450GP-1. The activity of 3-hydroxylation was comparable with that of P450GP-1, but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2′,4′,5′-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed.
AB - Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2′,4′,5′-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450GP-1. The activity of 3-hydroxylation was comparable with that of P450GP-1, but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2′,4′,5′-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed.
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U2 - 10.1006/bbrc.1995.1991
DO - 10.1006/bbrc.1995.1991
M3 - Article
C2 - 7626059
AN - SCOPUS:0029123430
SN - 0006-291X
VL - 212
SP - 455
EP - 460
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -