Methylenetetrahydrofolate reductase polymorphism in childhood primary focal segmental glomerulosclerosis

Chaochun Zou, Hirokazu Tsukahara, Masahiro Hiraoka, Jiang Mizu, Yukiko Todoroki, Yusei Ohshima, Hideki Kimura, Kazuo Tsuzuki, Mitsufumi Mayumi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim:The purpose of this study was to evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) C/T polymorphism and the prevalence and course of focal segmental glomerulosclerosis (FSGS) in our pediatric population. Methods: Genotypes for MTHFR were determined in 15 primary FSGS patients (male/female, 6/9) and 238 control subjects (male/female, 110/128) by the polymerase chain reaction and restriction fragment length polymorphism method. Results: For the whole group, the genotype frequencies (CC/CT/TT) of MTHFR in FSGS and control subjects were almost comparable. The TT genotype was associated with early onset of the disease as compared with the CC genotype. Furthermore, all the patients with the TT genotype had steroid-resistant FSGS and developed into end-stage renal failure, while those carrying either CC or CT genotype did not. Conclusion: We speculate that the TT genotype may be associated with early development and progression of childhood FSGS. Confirmatory studies using larger and ethnically distinct populations are needed to reveal the role of homocysteine in FSGS with consideration of medical interventions.

Original languageEnglish
Pages (from-to)449-451
Number of pages3
Issue number2
Publication statusPublished - 2002
Externally publishedYes


  • Children
  • Focal segmental glomerulosclerosis
  • Methylenetetrahydrofolate reductase
  • Polymorphism

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology


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