Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

Panarat Arunrattiyakorn, Sunit Suksamrarn, Nuttika Suwannasai, Hiroshi Kanzaki

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.

Original languageEnglish
Pages (from-to)730-734
Number of pages5
Issue number8
Publication statusPublished - Jun 2011


  • Anti-mycobacterial activity
  • Microbial metabolism
  • Sulfation
  • α-Mangostin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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