TY - JOUR
T1 - Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.
AU - Arunrattiyakorn, Panarat
AU - Suksamrarn, Sunit
AU - Suwannasai, Nuttika
AU - Kanzaki, Hiroshi
N1 - Funding Information:
This work was carried out in part under the collaboration of a scientific cooperation program between the National Research Council of Thailand (NRCT) and the Japan Society for the Promotion of Science (JSPS) under the Asian Core Program on Capacity Building and Development of Microbial Potential and Fermentation Technology towards a New Era. Support from The Strategic Research Grant, The Thailand Research Fund was gratefully acknowledged. The authors wish to express their thanks to Associate Prof. Teruhiko Nitoda of the Graduate School of Natural Science and Technology, Okayama University, for the mass analysis.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/6
Y1 - 2011/6
N2 - α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.
AB - α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.
KW - Anti-mycobacterial activity
KW - Microbial metabolism
KW - Sulfation
KW - α-Mangostin
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U2 - 10.1016/j.phytochem.2011.02.007
DO - 10.1016/j.phytochem.2011.02.007
M3 - Article
C2 - 21377704
AN - SCOPUS:79954597523
SN - 0031-9422
VL - 72
SP - 730
EP - 734
JO - Phytochemistry
JF - Phytochemistry
IS - 8
ER -
