Microbial metalloproteases and pathogenesis

Shin ichi Miyoshi, Sumio Shinoda

Research output: Contribution to journalReview articlepeer-review

289 Citations (Scopus)


Zinc metalloproteases produced by human pathogenic microorganisms show a wide variety of pathological actions. In local infections, the proteases cause necrotic or hemorrhagic tissue damage through digestion of structural components of the ground substance, and also form edematous lesions through generation of inflammatory mediators, while in systemic infections, the proteases act as a synergistic virulence factor through disordered proteolysis of many plasma proteins. Clostridial neurotoxins, Bacteroides fragilis enterotoxin and Bacillus anthracis lethal factor are also zinc metalloproteases. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalMicrobes and Infection
Issue number1
Publication statusPublished - Jan 2000


  • Exotoxin
  • Metalloprotease
  • Metalloproteinase

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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