Microfluidic extraction of docosahexaenoic acid ethyl ester: Comparison between slug flow and emulsion

Eiji Kamio, Yu Seike, Hidekazu Yoshizawa, Hideto Matsuyama, Tsutomu Ono

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Microfluidic liquid-liquid extraction of the ethyl ester of docosahexaenoic acid (DHA-Et) with silver ions was investigated using slug flow and a water-in-oil (W/O) emulsion as specific flow patterns possessing large interfacial areas. To compare the extraction rates of both systems, slug flow and a W/O emulsion with similar specific interfacial areas were prepared. Extraction rates for the systems were the same at 298 K. However, at 268 K, slug flow had a faster extraction rate than the W/O emulsion. Theoretical calculation follows the results for both systems at 298 K and for the slug flow system at 268 K, suggesting that the emulsion stabilizer inhibits complex formation between DHA-Et and silver ions at the O/W interface. A reduction in extraction rate was observed in the slug flow system at 268 K when the emulsion stabilizer was used. Slug flow can be prepared without stabilizer, offering advantages over emulsions in microfluidic extraction.

Original languageEnglish
Pages (from-to)6915-6924
Number of pages10
JournalIndustrial and Engineering Chemistry Research
Issue number11
Publication statusPublished - Jun 1 2011

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering


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