MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)

Megumi Yanokura; Kouji Banno; Yusuke Kobayashi; Iori Kisu; Arisa Ueki; Asuka Ono; Kennta Masuda; Hiroyuki Nomura; Akira Hirasawa; Nobuyuki Susumu; Daisuke Aoki

doi:10.3892/ol.2010.173

MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)

Megumi Yanokura, Kouji Banno, Yusuke Kobayashi, Iori Kisu, Arisa Ueki, Asuka Ono, Kennta Masuda, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a relationship between human diseases and the breakdown of gene silencing mechanisms induced by miRNA abnormalities. In particular, abnormal miRNA expression has been detected in various types of cancer and the target genes have been identified. These results indicate that miRNAs act in a manner equivalent to oncogenes or tumor suppressors. miRNAs may also serve as diagnostic biomarkers and therapeutic targets. In this review, we introduce the latest findings on miRNAs in human endometrial cancer, a common malignancy, and discuss the potential of miRNAs as biomarkers and targets for molecular therapy.

Original language	English
Pages (from-to)	935-940
Number of pages	6
Journal	Oncology Letters
Volume	1
Issue number	6
DOIs	https://doi.org/10.3892/ol.2010.173
Publication status	Published - Nov 2010
Externally published	Yes

Keywords

Biomarker
Endometrial cancer
MicroRNA
Therapeutic drugs

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ol.2010.173

Cite this

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abstract = "MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a relationship between human diseases and the breakdown of gene silencing mechanisms induced by miRNA abnormalities. In particular, abnormal miRNA expression has been detected in various types of cancer and the target genes have been identified. These results indicate that miRNAs act in a manner equivalent to oncogenes or tumor suppressors. miRNAs may also serve as diagnostic biomarkers and therapeutic targets. In this review, we introduce the latest findings on miRNAs in human endometrial cancer, a common malignancy, and discuss the potential of miRNAs as biomarkers and targets for molecular therapy.",

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AU - Yanokura, Megumi

AU - Banno, Kouji

AU - Kobayashi, Yusuke

AU - Kisu, Iori

AU - Ueki, Arisa

AU - Ono, Asuka

AU - Masuda, Kennta

AU - Nomura, Hiroyuki

AU - Hirasawa, Akira

AU - Susumu, Nobuyuki

AU - Aoki, Daisuke

PY - 2010/11

Y1 - 2010/11

N2 - MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a relationship between human diseases and the breakdown of gene silencing mechanisms induced by miRNA abnormalities. In particular, abnormal miRNA expression has been detected in various types of cancer and the target genes have been identified. These results indicate that miRNAs act in a manner equivalent to oncogenes or tumor suppressors. miRNAs may also serve as diagnostic biomarkers and therapeutic targets. In this review, we introduce the latest findings on miRNAs in human endometrial cancer, a common malignancy, and discuss the potential of miRNAs as biomarkers and targets for molecular therapy.

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KW - Biomarker

KW - Endometrial cancer

KW - MicroRNA

KW - Therapeutic drugs

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MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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