TY - JOUR
T1 - MicroRNAs in soft tissue sarcomas
T2 - Overview of the accumulating evidence and importance as novel biomarkers
AU - Fujiwara, Tomohiro
AU - Kunisada, Toshiyuki
AU - Takeda, Ken
AU - Uotani, Koji
AU - Yoshida, Aki
AU - Ochiya, Takahiro
AU - Ozaki, Toshifumi
N1 - Publisher Copyright:
© 2014 Tomohiro Fujiwara et al.
PY - 2014
Y1 - 2014
N2 - Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas have provided clues to solving these problems. Evidence of circulating miRNAs in patients with soft tissue sarcomas and healthy individuals has been accumulated and is accelerating their potential to develop into clinical applications. Moreover, miRNAs that function as novel prognostic factors have been identified, thereby facilitating their use in miRNA-targeted therapy. In this review, we provide an overview of the current knowledge on miRNA deregulation in soft tissue sarcomas, and discuss their potential as novel biomarkers and therapeutics.
AB - Sarcomas are distinctly heterogeneous tumors and a variety of subtypes have been described. Although several diagnostic explorations in the past three decades, such as identification of chromosomal translocation, have greatly improved the diagnosis of soft tissue sarcomas, the unsolved issues, including the limited useful biomarkers, remain. Emerging reports on miRNAs in soft tissue sarcomas have provided clues to solving these problems. Evidence of circulating miRNAs in patients with soft tissue sarcomas and healthy individuals has been accumulated and is accelerating their potential to develop into clinical applications. Moreover, miRNAs that function as novel prognostic factors have been identified, thereby facilitating their use in miRNA-targeted therapy. In this review, we provide an overview of the current knowledge on miRNA deregulation in soft tissue sarcomas, and discuss their potential as novel biomarkers and therapeutics.
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U2 - 10.1155/2014/592868
DO - 10.1155/2014/592868
M3 - Review article
C2 - 25165708
AN - SCOPUS:84929050834
SN - 2314-6133
VL - 2014
JO - BioMed research international
JF - BioMed research international
M1 - 592868
ER -