MiRNA expression atlas in male rat

Keiichi Minami; Takeki Uehara; Yuji Morikawa; Ko Omura; Masayuki Kanki; Akira Horinouchi; Atsushi Ono; Hiroshi Yamada; Yasuo Ohno; Tetsuro Urushidani

doi:10.1038/sdata.2014.5

MiRNA expression atlas in male rat

Keiichi Minami, Takeki Uehara, Yuji Morikawa, Ko Omura, Masayuki Kanki, Akira Horinouchi, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

Original language	English
Article number	140005
Journal	Scientific Data
Volume	1
DOIs	https://doi.org/10.1038/sdata.2014.5
Publication status	Published - May 27 2014
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Information Systems
Education
Computer Science Applications
Statistics, Probability and Uncertainty
Library and Information Sciences

Access to Document

10.1038/sdata.2014.5

Cite this

@article{bac77bbc8a1d43b8ba0e5b698964f354,

title = "MiRNA expression atlas in male rat",

abstract = "MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.",

author = "Keiichi Minami and Takeki Uehara and Yuji Morikawa and Ko Omura and Masayuki Kanki and Akira Horinouchi and Atsushi Ono and Hiroshi Yamada and Yasuo Ohno and Tetsuro Urushidani",

year = "2014",

month = may,

day = "27",

doi = "10.1038/sdata.2014.5",

language = "English",

volume = "1",

journal = "Scientific Data",

issn = "2052-4463",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - MiRNA expression atlas in male rat

AU - Minami, Keiichi

AU - Uehara, Takeki

AU - Morikawa, Yuji

AU - Omura, Ko

AU - Kanki, Masayuki

AU - Horinouchi, Akira

AU - Ono, Atsushi

AU - Yamada, Hiroshi

AU - Ohno, Yasuo

AU - Urushidani, Tetsuro

PY - 2014/5/27

Y1 - 2014/5/27

N2 - MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

AB - MicroRNAs (miRNAs) are small (∼22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

UR - http://www.scopus.com/inward/record.url?scp=84919859919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919859919&partnerID=8YFLogxK

U2 - 10.1038/sdata.2014.5

DO - 10.1038/sdata.2014.5

M3 - Article

C2 - 25977763

AN - SCOPUS:84919859919

SN - 2052-4463

VL - 1

JO - Scientific Data

JF - Scientific Data

M1 - 140005

ER -

MiRNA expression atlas in male rat

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this