Mirtazapine Was Effective for a Patient with Benzodiazepine Dependence

Manabu Takaki, Ryo Ishikawa, Shinji Sakamoto, Nozomu Hashimoto, Yuko Okahisa, Norihito Yamada

Research output: Contribution to journalArticlepeer-review


Objective Benzodiazepine (BZD) dependence has become a social problem and results in poor outcomes. Only a few evidence-based treatments for pharmacotherapy, including antidepressants, are recommended. Methods We reported about a 71-year-old man with onset of blindness at 50 years of age due to pigmentary degeneration of the retina developed insomnia at age 59 years, characterized by nocturnal and early morning awakenings. Results Mirtazapine was effective to not only treat sleep disturbance but also a craving for BZD. Conclusions The increases of dopamine, norepinephrine, and serotonin signaling by mirtazapine may be related to the effectiveness in reducing BZD dependence.

Original languageEnglish
Pages (from-to)11-12
Number of pages2
JournalClinical Neuropharmacology
Issue number1
Publication statusPublished - Jan 1 2022


  • benzodiazepine dependence
  • blind patient
  • craving
  • mirtazapine
  • withdrawal

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology


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