Model analysis of coronary hemodynamics incorporating autoregulation

Mitsuyasu Kagiyama, Hiroyuki Michinishi, Hiroto Kagotani, Takuji Okamoto, Yasuo Ogasawara, Fumihiko Kajiya

    Research output: Contribution to journalArticlepeer-review


    This paper models the autoregulation function for the coronary circulation and analyzes the pulsatile coronary hemodynamics. The autoregulation function acts to maintain a constant average blood flow in the arterioles, as determined by the oxygen consumption in the heart muscle, even if the average coronary arterial pressure changes. The regulation is realized by partially controlling the vessel characteristics which correspond to the vessel tonus. In this study, the function is incorporated into the existing three-layered coronary hemodynamics model. Then, the arteriole hemodynamics is analyzed by simulation for the case of the normal coronary arterial pressure waveform and for the case of systolic hypertension.

    Original languageEnglish
    Pages (from-to)21-31
    Number of pages11
    JournalSystems and Computers in Japan
    Issue number14
    Publication statusPublished - Dec 2004


    • Arteriole
    • Autoregulation
    • Blood flow
    • Coronary circulation
    • Simulation

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Information Systems
    • Hardware and Architecture
    • Computational Theory and Mathematics


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