TY - JOUR
T1 - Models for studying DNA methylation in human cancer
T2 - A review of current status
AU - Toyooka, Shinichi
AU - Shimizu, Nobuyoshi
PY - 2004/10
Y1 - 2004/10
N2 - In cancer epigenetics, aberrant methylation in the promoter is one of the key mechanisms for gene inactivation resulting in carcinogenesis in humans. Unique models have been utilized for studying methylation, for example, to determine the methylation profile, to study the mechanisms of methylation, and to investigate therapeutic interventions against cancer In humans. It is considered that further development of would be highly useful for further understanding and controlling cancer in humans.
AB - In cancer epigenetics, aberrant methylation in the promoter is one of the key mechanisms for gene inactivation resulting in carcinogenesis in humans. Unique models have been utilized for studying methylation, for example, to determine the methylation profile, to study the mechanisms of methylation, and to investigate therapeutic interventions against cancer In humans. It is considered that further development of would be highly useful for further understanding and controlling cancer in humans.
UR - http://www.scopus.com/inward/record.url?scp=23744436846&partnerID=8YFLogxK
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U2 - 10.1016/j.ddmod.2004.01.002
DO - 10.1016/j.ddmod.2004.01.002
M3 - Review article
AN - SCOPUS:23744436846
SN - 1740-6757
VL - 1
SP - 37
EP - 42
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 1
ER -
