TY - JOUR
T1 - Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse
AU - Faralli, Alessio
AU - Dagna, Federico
AU - Albera, Andrea
AU - Bekku, Yoko
AU - Oohashi, Toshitaka
AU - Albera, Roberto
AU - Rossi, Ferdinando
AU - Carulli, Daniela
N1 - Funding Information:
This work was supported by MIUR ex-60 % and PRIN 20107MSMA4 Grants (to D.C. and F.R.) and a Grant-in-Aid for Scientific Research on Innovative Areas (Grant No. 24110509 and No. 26110713) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan (to T.O.).
Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult brain. However, it is not known whether spontaneous PNN changes are functional to plasticity and repair after injury. To address this issue, we investigated PNN expression in the vestibular nuclei of the adult mouse during vestibular compensation, namely the resolution of motor deficits resulting from a unilateral peripheral vestibular lesion. After unilateral labyrinthectomy, we found that PNN number and staining intensity were strongly attenuated in the lateral vestibular nucleus on both sides, in parallel with remodelling of excitatory and inhibitory afferents. Moreover, PNNs were completely restored when vestibular deficits of the mice were abated. Interestingly, in mice with genetically reduced PNNs, vestibular compensation was accelerated. Overall, these results strongly suggest that temporal tuning of PNN expression may be crucial for vestibular compensation.
AB - Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult brain. However, it is not known whether spontaneous PNN changes are functional to plasticity and repair after injury. To address this issue, we investigated PNN expression in the vestibular nuclei of the adult mouse during vestibular compensation, namely the resolution of motor deficits resulting from a unilateral peripheral vestibular lesion. After unilateral labyrinthectomy, we found that PNN number and staining intensity were strongly attenuated in the lateral vestibular nucleus on both sides, in parallel with remodelling of excitatory and inhibitory afferents. Moreover, PNNs were completely restored when vestibular deficits of the mice were abated. Interestingly, in mice with genetically reduced PNNs, vestibular compensation was accelerated. Overall, these results strongly suggest that temporal tuning of PNN expression may be crucial for vestibular compensation.
KW - Axonal plasticity
KW - Bral2
KW - Chondroitin sulphate proteoglycans
KW - Perineuronal nets
KW - Vestibular compensation
KW - Vestibular nuclei
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U2 - 10.1007/s00429-015-1095-7
DO - 10.1007/s00429-015-1095-7
M3 - Article
C2 - 26264050
AN - SCOPUS:84939125911
SN - 1863-2653
VL - 221
SP - 3193
EP - 3209
JO - Brain Structure and Function
JF - Brain Structure and Function
IS - 6
ER -