Modulation by static magnetism of neuronal activity

Takao Hirai, Yasuaki Goto, Takeshi Takarada, Hideo Taniura, Yukio Yoneda

Research output: Contribution to journalReview articlepeer-review


In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the elucidation of mechanisms underlying the neurotransmission at synapses, while relatively little attention has been paid to the comprehensive evaluation of the conduction except for local anesthetics. According to a physical theorem, exposure to magnetism should lead to the generation of a certain mechanical force in neurons with concomitant electric currents in a particular situation. In particular, repetitive transcranial magnetic stimulation is beneficial for the treatment of selected patients suffering from depression, bipolar affective disorder and schizophrenia as a possible alternative to the electroconvulsive therapy for refractory depression. In this review, therefore, we will summarize our recent advances made on the neurochemical and molecular biological elucidation in cultured rat hippocampal neurons toward better understanding by the readers of different disciplines of mechanisms associated with the modulation by magnetism of the neuronal activity in the brain.

Original languageEnglish
Pages (from-to)21-35
Number of pages15
JournalBiomedical Reviews
Issue number1
Publication statusPublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Modulation by static magnetism of neuronal activity'. Together they form a unique fingerprint.

Cite this