Molecular evolution of yeast thiolase isozymes

Naoki Kanayama, Mitsuyoshi Ueda, Haruyuki Atomi, Tatsuo Kurihara, Atsuo Tanaka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The coexistence of two thiolase isozymes (acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase), essential for the complete degradation of fatty acids, only in peroxisomes of an n-alkane-utilizing yeast Candida tropicalis (Kurihara et al., J. Biochem., 106, 474-478, 1989) is unique in eukaryotic cells. As one of the methods of analysis of molecular information from these isozymes, the calculation of the evolutional distance among thiolases from various organisms suggested that yeast peroxisomal thiolase isozymes are important enzymes in examining the molecular evolution of the fatty acid metabolic pathway and the biogenesis of peroxisomes.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Fermentation and Bioengineering
Issue number4
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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