Molecular mechanisms of cardiac amyloidosis

Yukihiro Saito; Kazufumi Nakamura; Hiroshi Ito

doi:10.3390/ijms23010025

Molecular mechanisms of cardiac amyloidosis

Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precur-sor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.

Original language	English
Article number	25
Journal	International journal of molecular sciences
Volume	23
Issue number	1
DOIs	https://doi.org/10.3390/ijms23010025
Publication status	Published - Jan 1 2022

Keywords

Amyloid
Cytotoxicity
Immunoglobulin light chain
Transthyretin

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23010025

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title = "Molecular mechanisms of cardiac amyloidosis",

abstract = "Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precur-sor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.",

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AU - Saito, Yukihiro

AU - Nakamura, Kazufumi

AU - Ito, Hiroshi

PY - 2022/1/1

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N2 - Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precur-sor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.

AB - Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precur-sor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.

KW - Amyloid

KW - Cytotoxicity

KW - Immunoglobulin light chain

KW - Transthyretin

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Molecular mechanisms of cardiac amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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