Molecular pathology of transgenic tau mice

Tetsuro Murakami, Takeshi Kawarabayashi, Etsuro Matsubara, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticlepeer-review


Tau protein is a major component of neurofibrillary tangles (NFTs) in Alzheimer's disease. Mutations in the tau gene cause frontotemporal dementia linked to chromosome 17 (FTDP-17). Tau filament formation without Aβ accumulation is one of the characteristics of FTDP-17. Discovery of mutations in the gene demonstrated that dysfunction of tau can cause neurodegeneration and dementia. Several lines of transgenic (Tg) mice carrying tau mutations found in families with FTDP-17 have been generated to clarify the mechanism of Alzheimer's disease and other neurodegenerative disorders characterized by aberrant accumulation of tau protein in the central nervous system (tauopathy). In the present article, we make a review on transgenic tau mice, which would be of great help for the solution of molecular pathology and the establishment of therapeutics for tauopathy.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalInternational Congress Series
Issue numberC
Publication statusPublished - Jun 1 2003
Externally publishedYes


  • Frontotemporal dementia linked to chromosome 17 (FTDP-17)
  • Mutation
  • Tau
  • Transgenic mice

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Molecular pathology of transgenic tau mice'. Together they form a unique fingerprint.

Cite this