Molecular-targeted Therapy for Metastatic Renal Cell Carcinoma As First-line Therapy: A Single Institution 13-year Experience

Kensuke Bekku, Takuji Tsugawa, Kazuma Tsuboi, Gaku Noda, Yousuke Inoue, Wataru Murao, Shin Ebara

Research output: Contribution to journalArticlepeer-review


We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalActa medica Okayama
Issue number4
Publication statusPublished - 2022
Externally publishedYes


  • Immuno-checkpoint inhibitor
  • Metastatic renal cell carcinoma
  • Molecular-targeted therapy
  • Real-world setting

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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