Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats

Toru Egashira; Fusako Takayama; Yasumitsu Yamanaka; Yasuhiro Komatsu

doi:10.1254/jjp.80.379

Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats

Toru Egashira, Fusako Takayama, Yasumitsu Yamanaka, Yasuhiro Komatsu

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O₂^-), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O₂^-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

Original language	English
Pages (from-to)	379-382
Number of pages	4
Journal	Japanese Journal of Pharmacology
Volume	80
Issue number	4
DOIs	https://doi.org/10.1254/jjp.80.379
Publication status	Published - 1999
Externally published	Yes

Keywords

Pharmacodynamics
Radical scavenger
Sho-saiko-to (Kampo medicine)

ASJC Scopus subject areas

Pharmacology

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10.1254/jjp.80.379

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abstract = "The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.",

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AU - Egashira, Toru

AU - Takayama, Fusako

AU - Yamanaka, Yasumitsu

AU - Komatsu, Yasuhiro

PY - 1999

Y1 - 1999

N2 - The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

AB - The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

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KW - Radical scavenger

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Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats

Abstract

Keywords

ASJC Scopus subject areas

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