Morphine‐Induced Changes in Histamine Dynamics in Mouse Brain

Masahiro Nishibori, Ryozo Oishi, Yoshinori Itoh, Kiyomi Saeki

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64 Citations (Scopus)


Abstract: The effect of the acute morphine treatment on histamine (HA) pools in the brain and the spinal cord was examined in mice. Morphine (1–50 mg/kg, s.c.) administered alone caused no significant change in the steadystate levels of HA and its major metabolite, tele‐methylhistamine (t‐MH), in the brain. However, depending on the doses tested, morphine significantly enhanced the pargyline (65 mg/kg, i.p.)‐induced accumulation of t‐MH and this effect was antagonized by naloxone. A specific inhibitor of histidine decarboxylase, α‐fluoromethylhistidine (α‐FMH) (50 mg/kg, i.p.), decreased the brain HA level in consequence of the almost complete depletion of the HA pool with a rapid turnover. Morphine further decreased the brain HA level in α‐FMH‐pretreated mice. Morphine administered alone significantly reduced the HA level in the spinal cord, an area where the turnover of HA is very slow. These results suggest that the acute morphine treatment increases the turnover of neuronal HA via opioid receptors, and this opiate also releases HA from a slowly turning over pool(s).

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalJournal of Neurochemistry
Issue number3
Publication statusPublished - Sept 1985


  • Brain histamine
  • Histamine release
  • Histamine turnover
  • Histaminergic neuron
  • Methylhistamine
  • Morphine
  • tele

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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