Morphological changes in the hippocampus in amygdaloid kindled mouse

Jiro Hosokawa; Toshifumi Itano; Toyoyuki Usuki; Masaaki Tokuda; Hideki Matsui; Najma A. Janjua; Hiroshi Suwaki; Yasushi Okada; Tetsuro Negi; Tetuhide H. Murakami; Ryoji Konishi; Osamu Hatase

doi:10.1016/0920-1211(94)00058-5

Morphological changes in the hippocampus in amygdaloid kindled mouse

Jiro Hosokawa, Toshifumi Itano, Toyoyuki Usuki, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetsuro Negi, Tetuhide H. Murakami, Ryoji Konishi, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

To clarify the origin and maintenance of epileptogenesis, morphological changes in the hippocampus of amygdaloid-kindled mice were analyzed at different stages of kindling. The granule cell size in dentate gyrus and the pyramidal cell size in CA1 were clearly decreased depending on seizure stage. The cell size in CA2 was increased and density in dentate gyrus and CA2 was reduced, significantly. The morphological changes in hippocampus associated with kindling must be closely related to the acquisition and the maintenance of epileptogenesis. The results support the hypothesis that seizure-induced damage of neurons may lead to formation of new synaptic connections that produce abnormal hyperexitability and result in seizures.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	Epilepsy Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0920-1211(94)00058-5
Publication status	Published - Jan 1995

Keywords

Hippocampus
Kindling
Morphological changes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/0920-1211(94)00058-5

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title = "Morphological changes in the hippocampus in amygdaloid kindled mouse",

abstract = "To clarify the origin and maintenance of epileptogenesis, morphological changes in the hippocampus of amygdaloid-kindled mice were analyzed at different stages of kindling. The granule cell size in dentate gyrus and the pyramidal cell size in CA1 were clearly decreased depending on seizure stage. The cell size in CA2 was increased and density in dentate gyrus and CA2 was reduced, significantly. The morphological changes in hippocampus associated with kindling must be closely related to the acquisition and the maintenance of epileptogenesis. The results support the hypothesis that seizure-induced damage of neurons may lead to formation of new synaptic connections that produce abnormal hyperexitability and result in seizures.",

keywords = "Hippocampus, Kindling, Morphological changes",

author = "Jiro Hosokawa and Toshifumi Itano and Toyoyuki Usuki and Masaaki Tokuda and Hideki Matsui and Janjua, {Najma A.} and Hiroshi Suwaki and Yasushi Okada and Tetsuro Negi and Murakami, {Tetuhide H.} and Ryoji Konishi and Osamu Hatase",

note = "Funding Information: This work was supportedb y a Grant-in-Aidf or ScientificR esearchfr om the Ministry of Education, Sciencea nd Cultureo f Japan, and by Grantsf rom the Japan Epilepsy Researcih Foundation and KobayashMi edicalF oundation.",

year = "1995",

month = jan,

doi = "10.1016/0920-1211(94)00058-5",

language = "English",

volume = "20",

pages = "11--20",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier",

number = "1",

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T1 - Morphological changes in the hippocampus in amygdaloid kindled mouse

AU - Hosokawa, Jiro

AU - Itano, Toshifumi

AU - Usuki, Toyoyuki

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Janjua, Najma A.

AU - Suwaki, Hiroshi

AU - Okada, Yasushi

AU - Negi, Tetsuro

AU - Murakami, Tetuhide H.

AU - Konishi, Ryoji

AU - Hatase, Osamu

N1 - Funding Information: This work was supportedb y a Grant-in-Aidf or ScientificR esearchfr om the Ministry of Education, Sciencea nd Cultureo f Japan, and by Grantsf rom the Japan Epilepsy Researcih Foundation and KobayashMi edicalF oundation.

PY - 1995/1

Y1 - 1995/1

N2 - To clarify the origin and maintenance of epileptogenesis, morphological changes in the hippocampus of amygdaloid-kindled mice were analyzed at different stages of kindling. The granule cell size in dentate gyrus and the pyramidal cell size in CA1 were clearly decreased depending on seizure stage. The cell size in CA2 was increased and density in dentate gyrus and CA2 was reduced, significantly. The morphological changes in hippocampus associated with kindling must be closely related to the acquisition and the maintenance of epileptogenesis. The results support the hypothesis that seizure-induced damage of neurons may lead to formation of new synaptic connections that produce abnormal hyperexitability and result in seizures.

AB - To clarify the origin and maintenance of epileptogenesis, morphological changes in the hippocampus of amygdaloid-kindled mice were analyzed at different stages of kindling. The granule cell size in dentate gyrus and the pyramidal cell size in CA1 were clearly decreased depending on seizure stage. The cell size in CA2 was increased and density in dentate gyrus and CA2 was reduced, significantly. The morphological changes in hippocampus associated with kindling must be closely related to the acquisition and the maintenance of epileptogenesis. The results support the hypothesis that seizure-induced damage of neurons may lead to formation of new synaptic connections that produce abnormal hyperexitability and result in seizures.

KW - Hippocampus

KW - Kindling

KW - Morphological changes

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AN - SCOPUS:0028857435

SN - 0920-1211

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EP - 20

JO - Epilepsy Research

JF - Epilepsy Research

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ER -

Morphological changes in the hippocampus in amygdaloid kindled mouse

Abstract

Keywords

ASJC Scopus subject areas

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