Morphological changes of regional lymph node in squamous cell carcinoma of the oral cavity

Masaya Okura, Hajime Kagamiuchi, Gyo Tominaga, Seiji Iida, Yasuo Fukuda, Mikihiko Kogo

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


BACKGROUND: Regional immune responses with various types of cancer have been studied histopathologically, however, the prognostic value remains conflicting. The aim of this study was to evaluate morphological changes related to lymph node metastasis and the prognostic value for oral cavity squamous cell carcinoma. METHODS: With histopathologic whole architecture of 430 lymph nodes, gross area, germinal center (GC) area, paracortical area (PA), and tumor area were measured. RESULTS: Hetastatic node had significantly lower distribution ratio of PA to lymphoarea than that of tumor-free node. GC area was not constantly associated with lymph node metastasis. In Cox multivariate analysis, the mean ratio of PA to gross area/lymphoarea was an independent prognostic factor. CONCLUSIONS: The proportion of PA to gross/lymph area was associated with lymph node metastasis and long-term survival and may be useful in stratification of those patients for a requirement of adjuvant treatments.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalJournal of Oral Pathology and Medicine
Issue number4
Publication statusPublished - Apr 1 2005
Externally publishedYes


  • Germinal center
  • Head and neck cancer
  • Host immune response
  • Immunosuppression
  • Lymph node metastasis
  • Oral cavity cancer
  • Paracortical hyperplasia
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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