Multicentric Castleman's disease associated with inherited epidermolysis bullosa

Yoshio Kawakami; Akiko Nishibu; Satoshi Kikuchi; Mikio Ohtsuka; Koichiro Nakamura; Yoshihiro Nozawa; Masafumi Abe; Keiji Iwatsuki; Fumio Kaneko

doi:10.1111/j.1346-8138.2003.tb00459.x

Multicentric Castleman's disease associated with inherited epidermolysis bullosa

Yoshio Kawakami, Akiko Nishibu, Satoshi Kikuchi, Mikio Ohtsuka, Koichiro Nakamura, Yoshihiro Nozawa, Masafumi Abe, Keiji Iwatsuki, Fumio Kaneko

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.

Original language	English
Pages (from-to)	689-693
Number of pages	5
Journal	Journal of Dermatology
Volume	30
Issue number	9
DOIs	https://doi.org/10.1111/j.1346-8138.2003.tb00459.x
Publication status	Published - Sept 1 2003
Externally published	Yes

Keywords

Dystrophic epidermolysis bullosa
Hypergammaglobulinemia
Interleukin-6

ASJC Scopus subject areas

Dermatology

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10.1111/j.1346-8138.2003.tb00459.x

Cite this

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title = "Multicentric Castleman's disease associated with inherited epidermolysis bullosa",

abstract = "Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.",

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AU - Kawakami, Yoshio

AU - Nishibu, Akiko

AU - Kikuchi, Satoshi

AU - Ohtsuka, Mikio

AU - Nakamura, Koichiro

AU - Nozawa, Yoshihiro

AU - Abe, Masafumi

AU - Iwatsuki, Keiji

AU - Kaneko, Fumio

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.

AB - Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.

KW - Dystrophic epidermolysis bullosa

KW - Hypergammaglobulinemia

KW - Interleukin-6

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Multicentric Castleman's disease associated with inherited epidermolysis bullosa

Abstract

Keywords

ASJC Scopus subject areas

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