TY - JOUR
T1 - Multiple Roles of Histidine-Rich Glycoprotein in Vascular Homeostasis and Angiogenesis
AU - Gao, Shangze
AU - Nishibori, Masahiro
N1 - Funding Information:
Acknowledgments. The work was supported by a Grant-in-Aid for Scientific Research (no.19H03408 to M.N.), a Grant-in-Aid for Young Scientists (no.17K15580 to H.W.) from the Japan Society for the Promotion of Science (JSPS). The author S.G. was supported by a funding from Tsinghua University-Peking University Joint Center for Life Sciences.
Funding Information:
The work was supported by a Grant-in-Aid for Scientific Research (no.19H03408 to M.N.), a Grant-in-Aid for Young Scientists (no.17K15580 to H.W.) from the Japan Society for the Promotionof Science (JSPS). The author S.G. was supported by a funding from Tsinghua University-Peking University Joint Center for Life Sciences
Publisher Copyright:
© 2021, Acta Medica Okayama. All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many vertebrates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant andwell-characterized protein having a multidomain structure that enable it to interact with many ligands, functionas an adaptor molecule, and participate in numerous physiological and pathological processes. As aplasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis andangiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plasminogen)and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets).This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogenesisin various pathological conditions
AB - Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many vertebrates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant andwell-characterized protein having a multidomain structure that enable it to interact with many ligands, functionas an adaptor molecule, and participate in numerous physiological and pathological processes. As aplasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis andangiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plasminogen)and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets).This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogenesisin various pathological conditions
KW - Angiogenesis
KW - Coagulation
KW - Histidine-rich glycoprotein
KW - Vascular biology
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M3 - Article
C2 - 34955533
AN - SCOPUS:85122908972
SN - 0386-300X
VL - 75
SP - 671
EP - 675
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 6
ER -