Multiple Roles of Histidine-Rich Glycoprotein in Vascular Homeostasis and Angiogenesis

Shangze Gao, Masahiro Nishibori

Research output: Contribution to journalArticlepeer-review


Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many vertebrates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant andwell-characterized protein having a multidomain structure that enable it to interact with many ligands, functionas an adaptor molecule, and participate in numerous physiological and pathological processes. As aplasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis andangiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plasminogen)and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets).This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogenesisin various pathological conditions

Original languageEnglish
Pages (from-to)671-675
Number of pages5
JournalActa medica Okayama
Issue number6
Publication statusPublished - 2021
Externally publishedYes


  • Angiogenesis
  • Coagulation
  • Histidine-rich glycoprotein
  • Vascular biology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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