Multitracer screening: Brain delivery of trace elements by eight different administration methods

Yousuke Kanayama, Takae Tsuji, Shuichi Enomoto, Ryohei Amano

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.

Original languageEnglish
Pages (from-to)553-565
Number of pages13
Issue number6
Publication statusPublished - Dec 2005


  • Brain delivery
  • Multitracer
  • Trace element

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys


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