TY - JOUR
T1 - Multitracer study on the uptake of various trace elements in anemic rats
T2 - influence of NaFeEDTA and ferrous sulfate
AU - Igarashi, Kaori
AU - Nakanishi, Yukiko
AU - Hirunuma, Rieko
AU - Enomoto, Shuichi
AU - Kimura, Shuichi
N1 - Funding Information:
This work is supported by a grant from the International Life Science Institute of Japan (ILSI Japan). The authors would like to acknowledge the assistance of the staff of the laboratory of Dr Kimura, Showa Women's University and Cyclotron Center, RIKEN. They also acknowledge the scientific suggestions of Dr Takeichi, Dr Takahashi, and Dr Takematsu (RIKEN).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/4
Y1 - 2006/4
N2 - Iron deficiency is one of the major nutritional problems in developing countries. Food fortification is assumed to be an effective method for enhancing iron absorption. Sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), a metal chelate, is one of the iron fortificants. It is a flavorless and inert compound. However, it is possible that EDTA may bind to metals other than iron and influence their absorption because of its strong chelating property. In this study, we determined the effect of NaFeEDTA on the absorption of various trace elements in the presence and absence of inhibitor using a multitracer technique. The multitracer is a carrier-free and salt-free solution containing a large number of radioactive nuclides. This method allows the simultaneous evaluation of behavior for a number of trace elements under strictly identical experimental conditions. As a result, incorporating NaFeEDTA into the rat diet did not lead to a deficiency in essential metals such as Zn, Mn, and Se in the presence of tannic acid. Furthermore, the uptake of various elements in the NaFeEDTA-fed rats is not inhibited by tannic acid. Thus, NaFeEDTA may be a suitable fortificant for improving iron-deficiency status in developing countries. Our findings in this study demonstrated that the multitracer technique provides us with many findings in nutritional research.
AB - Iron deficiency is one of the major nutritional problems in developing countries. Food fortification is assumed to be an effective method for enhancing iron absorption. Sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), a metal chelate, is one of the iron fortificants. It is a flavorless and inert compound. However, it is possible that EDTA may bind to metals other than iron and influence their absorption because of its strong chelating property. In this study, we determined the effect of NaFeEDTA on the absorption of various trace elements in the presence and absence of inhibitor using a multitracer technique. The multitracer is a carrier-free and salt-free solution containing a large number of radioactive nuclides. This method allows the simultaneous evaluation of behavior for a number of trace elements under strictly identical experimental conditions. As a result, incorporating NaFeEDTA into the rat diet did not lead to a deficiency in essential metals such as Zn, Mn, and Se in the presence of tannic acid. Furthermore, the uptake of various elements in the NaFeEDTA-fed rats is not inhibited by tannic acid. Thus, NaFeEDTA may be a suitable fortificant for improving iron-deficiency status in developing countries. Our findings in this study demonstrated that the multitracer technique provides us with many findings in nutritional research.
KW - Absorption
KW - Iron deficiency
KW - Multitracer technique
KW - NaFeEDTA
KW - Simultaneous tracing
KW - Trace elements
UR - http://www.scopus.com/inward/record.url?scp=33744913000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744913000&partnerID=8YFLogxK
U2 - 10.1016/j.nutres.2006.04.002
DO - 10.1016/j.nutres.2006.04.002
M3 - Article
AN - SCOPUS:33744913000
SN - 0271-5317
VL - 26
SP - 173
EP - 179
JO - Nutrition Research
JF - Nutrition Research
IS - 4
ER -
