Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Chizuru Sogawa, Yasuhiro Fujiwara, Satoshi Tsukamoto, Yuka Ishida, Yukie Yoshii, Takako Furukawa, Tetsuo Kunieda, Tsuneo Saga

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: C-type natriuretic peptide (CNP) signaling through its receptor natriuretic peptide receptor B (NPR-B) is a key molecule for mammalian reproduction, and known to play important roles in female fertility. However, the function of these peptides in mouse male reproduction remains largely unknown. To determine the role of CNP/NPR-B signaling in male reproduction we investigated phenotype of Npr2-deficient short-limbed-dwarfism (Npr2slw/slw) mice, which have been shown to have gastrointestinal (GI) abnormalities.Findings: In homozygous Npr2slw/slw mice, spermatogenesis is developmentally delayed at both 2 and 4 weeks of age, with vacuolation and degenerating apoptotic germ cells being observed at 3 weeks age. However, the adult Npr2slw/slw mice exhibited apparently normal spermatogenesis, albeit with some aberrant spermatids, suggesting that developmental delay was overcome. In addition, the adult Npr2slw/slw mice showed abnormal penile morphology (paraphimosis).Conclusions: The potential role of CNP signaling via the NPR-B receptor in male fertility appears to be mediated not through germ-cell development, but may be through maintenance of normal penile function.

Original languageEnglish
Article number64
JournalReproductive Biology and Endocrinology
Issue number1
Publication statusPublished - Jul 10 2014
Externally publishedYes


  • CNP
  • Infertility
  • NPR-B
  • Paraphimosis
  • SLW mouse
  • Smooth muscle
  • Spermatogenesis
  • cGMP

ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Developmental Biology


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