Myositis as a manifestation of chronic graft-versus-host disease

Koji Takahashi; Kenichi Kashihara; Katsuji Shinagawa; Tadashi Yoshino; Koji Abe; Mine Harada

doi:10.2169/internalmedicine.39.482

Myositis as a manifestation of chronic graft-versus-host disease

Koji Takahashi, Kenichi Kashihara, Katsuji Shinagawa, Tadashi Yoshino, Koji Abe, Mine Harada

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We report a 22-year-old man who had myositis in the course of chronic graft-versus-host disease after bone marrow transplantation for acute monocytic leukemia. The distribution of muscular involvement was different from idiopathic polymyositis. Muscular atrophy and weakness were noted in the distal muscles as well as in the proximal muscles of the upper extremities but there was little weakness in the proximal muscles of the lower extremities. However, histological and immunohistochemical study of the biceps brachii muscle showed findings similar to those of idiopathic polymyositis. It was suggested that myositis can be a manifestation of chronic GVHD caused by a cellular immune reaction by donor T cells.

Original language	English
Pages (from-to)	482-485
Number of pages	4
Journal	Internal Medicine
Volume	39
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.39.482
Publication status	Published - Jun 2000

Keywords

Bone marrow transplantation
Inflammatory myopathy
Polymyositis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.39.482

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abstract = "We report a 22-year-old man who had myositis in the course of chronic graft-versus-host disease after bone marrow transplantation for acute monocytic leukemia. The distribution of muscular involvement was different from idiopathic polymyositis. Muscular atrophy and weakness were noted in the distal muscles as well as in the proximal muscles of the upper extremities but there was little weakness in the proximal muscles of the lower extremities. However, histological and immunohistochemical study of the biceps brachii muscle showed findings similar to those of idiopathic polymyositis. It was suggested that myositis can be a manifestation of chronic GVHD caused by a cellular immune reaction by donor T cells.",

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AU - Kashihara, Kenichi

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AU - Abe, Koji

AU - Harada, Mine

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AB - We report a 22-year-old man who had myositis in the course of chronic graft-versus-host disease after bone marrow transplantation for acute monocytic leukemia. The distribution of muscular involvement was different from idiopathic polymyositis. Muscular atrophy and weakness were noted in the distal muscles as well as in the proximal muscles of the upper extremities but there was little weakness in the proximal muscles of the lower extremities. However, histological and immunohistochemical study of the biceps brachii muscle showed findings similar to those of idiopathic polymyositis. It was suggested that myositis can be a manifestation of chronic GVHD caused by a cellular immune reaction by donor T cells.

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Myositis as a manifestation of chronic graft-versus-host disease

Abstract

Keywords

ASJC Scopus subject areas

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