Myxofibrosarcoma: Clinical and prognostic value of mri features

Paolo Spinnato, Andrea Sambri, Tomohiro Fujiwara, Luca Ceccarelli, Roberta Clinca, Manuel R. Medellin, Massimiliano De Paolis, Davide M. Donati, Giuseppe Bianchi

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma, which plays a key role in the preoperative setting of these patients. MRI features associated with the high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement and presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful in stratifying the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalCurrent Medical Imaging
Issue number2
Publication statusPublished - 2021


  • Local neoplasm re-currence
  • Magnetic resonance imaging
  • Neoplasm invasivenes
  • Prognosis
  • Sarcoma
  • Soft tissue neoplasm

ASJC Scopus subject areas

  • Internal Medicine
  • Radiology Nuclear Medicine and imaging


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