Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

Yohei Takahashi; Takaaki Kubota; Junji Ito; Yuzuru Mikami; Jane Fromont; Jun'ichi Kobayashi

doi:10.1016/j.bmc.2008.07.028

Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

Yohei Takahashi, Takaaki Kubota, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.

Original language	English
Pages (from-to)	7561-7564
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	16
DOIs	https://doi.org/10.1016/j.bmc.2008.07.028
Publication status	Published - Aug 15 2008
Externally published	Yes

Keywords

Marine sponge
Nakijiquinones G-I
Sesquiterpenoid quinones

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2008.07.028

Cite this

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title = "Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge",

abstract = "Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.",

keywords = "Marine sponge, Nakijiquinones G-I, Sesquiterpenoid quinones",

author = "Yohei Takahashi and Takaaki Kubota and Junji Ito and Yuzuru Mikami and Jane Fromont and Jun'ichi Kobayashi",

note = "Funding Information: We thank Ms. S. Oka and A. Miyao, Center for Instrumental Analysis, Hokkaido University, for measurements of FAMBS, and Z. Nagahama, K. Uehara, and S. Furugen for their help with the sponge collection. This work was partly supported by a Grant-in-Aid from the Uehara Memorial Foundation and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. ",

year = "2008",

month = aug,

day = "15",

doi = "10.1016/j.bmc.2008.07.028",

language = "English",

volume = "16",

pages = "7561--7564",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

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TY - JOUR

T1 - Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

AU - Takahashi, Yohei

AU - Kubota, Takaaki

AU - Ito, Junji

AU - Mikami, Yuzuru

AU - Fromont, Jane

AU - Kobayashi, Jun'ichi

N1 - Funding Information: We thank Ms. S. Oka and A. Miyao, Center for Instrumental Analysis, Hokkaido University, for measurements of FAMBS, and Z. Nagahama, K. Uehara, and S. Furugen for their help with the sponge collection. This work was partly supported by a Grant-in-Aid from the Uehara Memorial Foundation and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.

AB - Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.

KW - Marine sponge

KW - Nakijiquinones G-I

KW - Sesquiterpenoid quinones

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DO - 10.1016/j.bmc.2008.07.028

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SN - 0968-0896

VL - 16

SP - 7561

EP - 7564

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 16

ER -

Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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