TY - JOUR
T1 - Nanomaterial scaffolds to regenerate musculoskeletal tissue
T2 - signals from within for neovessel formation
AU - Wang, Zuyong
AU - Wen, Feng
AU - Lim, Poon Nian
AU - Zhang, Qinyuan
AU - Konishi, Toshiisa
AU - Wang, Dong
AU - Teoh, Swee Hin
AU - Thian, Eng San
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/9
Y1 - 2017/9
N2 - Current treatments for musculoskeletal disease and injury are restricted with the usage of autografts and allografts. Tissue engineering that applies the principles of biology and engineering to develop functional substitutes has potential promise of therapeutic regeneration for musculoskeletal tissues. However, engineering sizable tissues needs a vascular network to supply cells with nutrients, oxygen and signals after implantation. For this purpose, recent developments on therapeutic nanomaterials have been explored in delivering different vessel-inductive growth factors, small biomolecules and ions for scalable engineering into vascularizable scaffolds. Here, we provide an overview on the current efforts, and propose future perspectives for precise regulation on vascularization processes and musculoskeletal tissue functionality.
AB - Current treatments for musculoskeletal disease and injury are restricted with the usage of autografts and allografts. Tissue engineering that applies the principles of biology and engineering to develop functional substitutes has potential promise of therapeutic regeneration for musculoskeletal tissues. However, engineering sizable tissues needs a vascular network to supply cells with nutrients, oxygen and signals after implantation. For this purpose, recent developments on therapeutic nanomaterials have been explored in delivering different vessel-inductive growth factors, small biomolecules and ions for scalable engineering into vascularizable scaffolds. Here, we provide an overview on the current efforts, and propose future perspectives for precise regulation on vascularization processes and musculoskeletal tissue functionality.
UR - http://www.scopus.com/inward/record.url?scp=85017332027&partnerID=8YFLogxK
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U2 - 10.1016/j.drudis.2017.03.010
DO - 10.1016/j.drudis.2017.03.010
M3 - Review article
C2 - 28363083
AN - SCOPUS:85017332027
SN - 1359-6446
VL - 22
SP - 1385
EP - 1391
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9
ER -