Nationwide survey of fertility preservation in patients with hematological malignancies in Japan

Sachiyo Okamoto, Nobuharu Fujii, Norihito Yoshioka, Miyuki Harada, Mitsune Tanimoto, Yoshinobu Maeda, Nao Suzuki, Yutaka Osuga

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Worldwide, there has been a growing interest in oncofertility issues. In 2017, the Japanese Society of Clinical Oncology published clinical practice guidelines for fertility preservation (FP) in cancer patients. We conducted a questionnaire survey to explore the FP practices among hematologists before the publication of this guideline. Methods: We sent 427 designated cancer hospitals in Japan a questionnaire about FP treatment for patients with hematological malignancies between January and December 2014. Results: Of these, 137 institutions responded, and 81 (19.0%) were included in the analysis. A total of 324 female and 441 male patients, aged < 40 years, were treated. The percentage of patients informed about FP was higher in patients treated with hematopoietic cell transplant than those without. Female patients were less likely to be informed about FP than male patients. FP was performed in a total of 27 female patients: 20 oocyte cryopreservation, 2 embryo cryopreservation, 3 ovarian tissue cryopreservation, and 2 ovarian shielding during total body irradiation. Sperm cryopreservation was performed in 115 male patients. Conclusions: Our findings indicate the reality of fertility preservation in 2014, before the guideline were issued. Further studies are warranted to investigate the improvement in fertility preservation since the guidelines were issued.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalInternational Journal of Clinical Oncology
Issue number2
Publication statusPublished - Feb 2021


  • Cryopreservation
  • Fertility preservation
  • Hematological malignancy
  • Oncofertility

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology


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