Necessity is the mother of invention: An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

Hiroki Kakuta

doi:10.1002/cmdc.200800095

Necessity is the mother of invention: An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

Hiroki Kakuta

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

(Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.

Original language	English
Pages (from-to)	1024-1025
Number of pages	2
Journal	ChemMedChem
Volume	3
Issue number	7
DOIs	https://doi.org/10.1002/cmdc.200800095
Publication status	Published - Jul 14 2008

Keywords

Cyclin D1
Inflammation
Nanoparticles
RNA interference
Systemic administration

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

Access to Document

10.1002/cmdc.200800095

Cite this

@article{a5b0bb7919d444ee838565cb3fd9bf4d,

title = "Necessity is the mother of invention: An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation",

abstract = "(Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.",

keywords = "Cyclin D1, Inflammation, Nanoparticles, RNA interference, Systemic administration",

author = "Hiroki Kakuta",

year = "2008",

month = jul,

day = "14",

doi = "10.1002/cmdc.200800095",

language = "English",

volume = "3",

pages = "1024--1025",

journal = "Farmaco",

issn = "1860-7179",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Necessity is the mother of invention

T2 - An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

AU - Kakuta, Hiroki

PY - 2008/7/14

Y1 - 2008/7/14

N2 - (Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.

AB - (Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.

KW - Cyclin D1

KW - Inflammation

KW - Nanoparticles

KW - RNA interference

KW - Systemic administration

UR - http://www.scopus.com/inward/record.url?scp=54849202900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54849202900&partnerID=8YFLogxK

U2 - 10.1002/cmdc.200800095

DO - 10.1002/cmdc.200800095

M3 - Review article

C2 - 18465763

AN - SCOPUS:54849202900

SN - 1860-7179

VL - 3

SP - 1024

EP - 1025

JO - Farmaco

JF - Farmaco

IS - 7

ER -

Necessity is the mother of invention: An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this