Negative regulation by FliD, FliS, and FliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium

Tatsuki Yokoseki, Tetsuo Iino, Kazuhiro Kutsukake

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum- specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.

    Original languageEnglish
    Pages (from-to)899-901
    Number of pages3
    JournalJournal of bacteriology
    Volume178
    Issue number3
    DOIs
    Publication statusPublished - Feb 1996

    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology

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