Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

Yoshinori Itoh, Masahiro Nishibori, Ryozo Oishi, Kiyomi Saeki

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Aug 10 1984


  • histamine
  • histidine
  • locomotor activity
  • methamphetamine
  • metoprine
  • mouse
  • tele-methylhistamine
  • α-fluoromethylhistidine

ASJC Scopus subject areas

  • General Neuroscience


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