TY - JOUR
T1 - Neuropathological comorbidity associated with argyrophilic grain disease
AU - Yokota, Osamu
AU - Miki, Tomoko
AU - Ikeda, Chikako
AU - Nagao, Shigeto
AU - Takenoshita, Shintaro
AU - Ishizu, Hideki
AU - Haraguchi, Takashi
AU - Kuroda, Shigetoshi
AU - Terada, Seishi
AU - Yamada, Norihito
N1 - Funding Information:
We thank Mses. Y Matsuo and M. Onbe for their technical assistance. This work was supported by Grants-in-Aid for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI Grant No. 15K09867), Grants-in-Aid from the Research Committee of CNS Degenerative Diseases and Research on Dementia from the Ministry of Health, Labour and Welfare of Japan (H29-Nanchi-Ippan-033), an Intramural Research Grant for Neurological and Psychiatric Disorders from National Center of Neurology and Psychiatry (NCNP) (27-6-2), grants from the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development (AMED, 17dm0107109h0002, 17kk0205009s0702), and grants from Zikei Institute of Psychiatry.
Publisher Copyright:
© 2017 Japanese Society of Neuropathology
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2% to 100%. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25%) had a few Gallyas-positive tufted astrocytes, six cases (30%) had a few granular/fuzzy astrocytes, and one case (5.0%) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25% when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.
AB - Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2% to 100%. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25%) had a few Gallyas-positive tufted astrocytes, six cases (30%) had a few granular/fuzzy astrocytes, and one case (5.0%) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25% when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.
KW - argyrophilic grains
KW - four repeat tau
KW - granular/fuzzy astrocytes
KW - progressive supranuclear palsy
KW - tufted astrocytes
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U2 - 10.1111/neup.12429
DO - 10.1111/neup.12429
M3 - Article
C2 - 28906054
AN - SCOPUS:85029429142
SN - 0919-6544
VL - 38
SP - 82
EP - 97
JO - Neuropathology
JF - Neuropathology
IS - 1
ER -