Neurosurgical therapy for parkinson's disease

S. Tomita, I. Date, T. Ohmoto

Research output: Contribution to journalReview articlepeer-review


Stereotactic surgery and neuronal transplantation are considered to be effective surgical therapies for advanced Parkinson's disease with wearing off phenomenon. As a stereotactic surgery, posteroventral pallidotomy and chronic pallidal or subthalamic stimulation with inhibitory parameters were performed. Flattening of the motor fluctuations were obtained with improving general motor symptoms especially at "off" time. Therapeutic l-dopa dose could not reduced following pallidotomy and pallidal stimulation, whereas subthalamic stimulation saved 30-50% of l-dopa dose. By the constant supply of dopamine, neuronal transplantation was effective on wearing off. Chromaffin cells of adrenal medulla and pretransected peripheral nerve were cografted into the bilateral caudate nuclei. After the transplantation significant reduction of % time off and l-dopa dose was observed.

Original languageEnglish
Pages (from-to)2105-2109
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number10
Publication statusPublished - Oct 2000

ASJC Scopus subject areas

  • Medicine(all)


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