Neurotropic influenza virus infections

Nobuko Yamashita

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Neurological complications of seasonal influenza virus (IV) infection are caused by the host immune response to IV infection because seasonal IV infections only affect the human respiratory epithelium and the viruses never invade the central nervous system (CNS). However, sporadic cases of human IV meningitis associated with highly pathogenic H5N1 have been reported since the late 1990s. The virulence of the H5N1 virus is largely due to mutation of the hemagglutinin gene, which mediates virus adsorption to host cells. The highly pathogenic H5N1 virus directly spreads from the nasal cavity via the olfactory nerve to the CNS in animal models.

Original languageEnglish
Title of host publicationNeurotropic Viral Infections
Subtitle of host publicationVolume 1: Neurotropic RNA Viruses
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783319331331
ISBN (Print)9783319331317
Publication statusPublished - Jan 1 2016
Externally publishedYes


  • Encephalitis
  • Encephalopathy
  • H5N1
  • Hemagglutinin gene
  • Highly pathogenic avian influenza virus
  • Influenza

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Immunology and Microbiology(all)


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