Neurotropic influenza virus infections

Nobuko Yamashita

doi:10.1007/978-3-319-33133-1_12

Neurotropic influenza virus infections

Nobuko Yamashita

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Neurological complications of seasonal influenza virus (IV) infection are caused by the host immune response to IV infection because seasonal IV infections only affect the human respiratory epithelium and the viruses never invade the central nervous system (CNS). However, sporadic cases of human IV meningitis associated with highly pathogenic H5N1 have been reported since the late 1990s. The virulence of the H5N1 virus is largely due to mutation of the hemagglutinin gene, which mediates virus adsorption to host cells. The highly pathogenic H5N1 virus directly spreads from the nasal cavity via the olfactory nerve to the CNS in animal models.

Original language	English
Title of host publication	Neurotropic Viral Infections
Subtitle of host publication	Volume 1: Neurotropic RNA Viruses
Publisher	Springer International Publishing
Pages	295-314
Number of pages	20
ISBN (Electronic)	9783319331331
ISBN (Print)	9783319331317
DOIs	https://doi.org/10.1007/978-3-319-33133-1_12
Publication status	Published - Jan 1 2016
Externally published	Yes

Keywords

Encephalitis
Encephalopathy
H5N1
Hemagglutinin gene
Highly pathogenic avian influenza virus
Influenza

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)
Immunology and Microbiology(all)

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10.1007/978-3-319-33133-1_12

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abstract = "Neurological complications of seasonal influenza virus (IV) infection are caused by the host immune response to IV infection because seasonal IV infections only affect the human respiratory epithelium and the viruses never invade the central nervous system (CNS). However, sporadic cases of human IV meningitis associated with highly pathogenic H5N1 have been reported since the late 1990s. The virulence of the H5N1 virus is largely due to mutation of the hemagglutinin gene, which mediates virus adsorption to host cells. The highly pathogenic H5N1 virus directly spreads from the nasal cavity via the olfactory nerve to the CNS in animal models.",

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AB - Neurological complications of seasonal influenza virus (IV) infection are caused by the host immune response to IV infection because seasonal IV infections only affect the human respiratory epithelium and the viruses never invade the central nervous system (CNS). However, sporadic cases of human IV meningitis associated with highly pathogenic H5N1 have been reported since the late 1990s. The virulence of the H5N1 virus is largely due to mutation of the hemagglutinin gene, which mediates virus adsorption to host cells. The highly pathogenic H5N1 virus directly spreads from the nasal cavity via the olfactory nerve to the CNS in animal models.

KW - Encephalitis

KW - Encephalopathy

KW - H5N1

KW - Hemagglutinin gene

KW - Highly pathogenic avian influenza virus

KW - Influenza

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SP - 295

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BT - Neurotropic Viral Infections

PB - Springer International Publishing

ER -

Neurotropic influenza virus infections

Abstract

Keywords

ASJC Scopus subject areas

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