TY - JOUR
T1 - New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae
AU - Tian, Jie Feng
AU - Li, Peng Ju
AU - Li, Xiao Xia
AU - Sun, Ping Hua
AU - Gao, Hao
AU - Liu, Xing Zhong
AU - Huang, Peng
AU - Tang, Jin Shan
AU - Yao, Xin Sheng
N1 - Funding Information:
The authors are grateful to Dr. Tao Shi, Jian-liang Geng and Mr. Tian-yu Sun for the HR ESI-MS and NMR measurements. Dr. Guo-dong Chen’s enthusiastic help in gene sequence analysis and uploading is also appreciated. We also gratefully acknowledge Dr. Wei-feng Ma, Southern Medical University of China for kindly providing the Pseudomonas aeruginosa resistant strain (PAOA). This work was supported by grants from the Ministry of Science and Technology of China (No. 2012ZX09301002003 ), by Guangdong Natural Science Funds for Distinguished Young Scholar (No. S2013050014287), and by the program for New Century Excellent Talents in University (No. NCET-10-0120).
Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Eight new isocoumarin glycosides (1-8) were obtained from the solid culture of the wetland soil-derived fungus Metarhizium anisopliae (No. DTH12-10). Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC spectra. The absolute configurations were determined by single crystal X-ray diffraction, circular dichroism (CD) spectrum, and chemical derivatization methods. In addition, inhibition of the biofilm formation and the secretion of virulence factor of the new isocoumarin glycosides against Pseudomonas aeruginosa strain PAOA (clinical isolates) were evaluated. The result revealed that compound 1 showed antibacterial activity comparable with (Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BF).
AB - Eight new isocoumarin glycosides (1-8) were obtained from the solid culture of the wetland soil-derived fungus Metarhizium anisopliae (No. DTH12-10). Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC spectra. The absolute configurations were determined by single crystal X-ray diffraction, circular dichroism (CD) spectrum, and chemical derivatization methods. In addition, inhibition of the biofilm formation and the secretion of virulence factor of the new isocoumarin glycosides against Pseudomonas aeruginosa strain PAOA (clinical isolates) were evaluated. The result revealed that compound 1 showed antibacterial activity comparable with (Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone (BF).
KW - 3,4-Dihydroisocoumarin glycoside
KW - Antibacterial activity
KW - Biofilm inhibitory activity
KW - Chemical constituents
KW - Metarhizium anisopliae
KW - Virulence factor secretion
UR - http://www.scopus.com/inward/record.url?scp=84957921595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957921595&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2016.01.074
DO - 10.1016/j.bmcl.2016.01.074
M3 - Article
C2 - 26848110
AN - SCOPUS:84957921595
SN - 0960-894X
VL - 26
SP - 1391
EP - 1396
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 5
ER -