New cytotoxic agents: A review of the literature

Katsuyuki Hotta, Hiroshi Ueoka

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


The goal of treatment for patients with advanced cancer is to prolong survival, control symptoms, and reduce disease-related complications. Despite the introduction of many cytotoxic agents during the past decade, only modest improvement in survival has been achieved. In order to urgently improve these situations, new cytotoxic agents as well as molecular-targeted agents are now under investigation. In this article, we reviewed the latest information regarding antitumor activity, toxicity, pharmacokinetics, and clinical application of the new cytotoxic agents.

Original languageEnglish
Pages (from-to)45-65
Number of pages21
JournalCritical Reviews in Oncology/Hematology
Issue number1
Publication statusPublished - Jul 2005


  • Cancer chemotherapy
  • Cytotoxic
  • New drug

ASJC Scopus subject areas

  • Hematology
  • Oncology


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