TY - JOUR
T1 - New cytotoxic agents
T2 - A review of the literature
AU - Hotta, Katsuyuki
AU - Ueoka, Hiroshi
PY - 2005/7
Y1 - 2005/7
N2 - The goal of treatment for patients with advanced cancer is to prolong survival, control symptoms, and reduce disease-related complications. Despite the introduction of many cytotoxic agents during the past decade, only modest improvement in survival has been achieved. In order to urgently improve these situations, new cytotoxic agents as well as molecular-targeted agents are now under investigation. In this article, we reviewed the latest information regarding antitumor activity, toxicity, pharmacokinetics, and clinical application of the new cytotoxic agents.
AB - The goal of treatment for patients with advanced cancer is to prolong survival, control symptoms, and reduce disease-related complications. Despite the introduction of many cytotoxic agents during the past decade, only modest improvement in survival has been achieved. In order to urgently improve these situations, new cytotoxic agents as well as molecular-targeted agents are now under investigation. In this article, we reviewed the latest information regarding antitumor activity, toxicity, pharmacokinetics, and clinical application of the new cytotoxic agents.
KW - Cancer chemotherapy
KW - Cytotoxic
KW - New drug
UR - http://www.scopus.com/inward/record.url?scp=20344403500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20344403500&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2005.01.006
DO - 10.1016/j.critrevonc.2005.01.006
M3 - Review article
C2 - 15927843
AN - SCOPUS:20344403500
SN - 1040-8428
VL - 55
SP - 45
EP - 65
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
IS - 1
ER -
