New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt

Salwa F. Farag, Yuka Kimura, Hideyuki Ito, Junko Takayasu, Harukuni Tokuda, Tsutomu Hatano

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Two new isoflavone glycosides, tectorigenin 7-O-β-d-glucopyranoside- 4′-O-[β-d-glucopyranosyl-(1‴′ → 6‴)-β-d-glucopyranoside] (1) and iristectorigenin B 4′-O-[β-d-glucopyranosyl-(1‴ → 6″)-β-d- glucopyranoside] (2), together with 11 known compounds, including six isoflavones, tectorigenin 7-O-β-d-glucopyranoside-4′-O-β-d- glucopyranoside (3), tectorigenin 4′-O-[β-d-glucopyranosyl-(1‴ → 6″)-β-d-glucopyranoside] (4), tectorigenin 7-O-β-d-glucopyranoside (5), genistein 7-O-β-d-glucopyranoside (6), tectorigenin 4′-O-β-d-glucopyranoside (7), and tectorigenin (8); two phenolic acid glycosides, vanillic acid 4-O-β-d-glucopyranoside (9) and glucosyringic acid (10); a phenylpropanoid glycoside, E-coniferin (11); an auronol derivative, maesopsin 6-O-β-d-glucopyranoside (12); and a pyrrole derivative, 4-(2-formyl-5-hydroxymethylpyrrol-1-yl) butyric acid (13), were isolated from fresh Iris spuria (Calizona) rhizomes. The structures of these compounds were established on the basis of spectroscopic and chemical evidence. Inhibitory effects on the activation of Epstein-Barr virus early antigen were examined for compounds 1-8 and 12.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - Jan 2009


  • Auronol
  • Iridaceae
  • Iris spuria
  • Isoflavone glycosides
  • Phenolic acid glycosides
  • Phenylpropanoid glycoside

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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