Abstract
The nm23-H1 gene is known as a potential metastasis suppressor gene in various types of carcinomas. However, the role of nm23-H1 in colorectal carcinoma still remains controversial and the cellular mechanisms by which its protein may modulate the metastatic phenotype are not yet known. We transfected nm23-H1 cDNA into the human colon cancer cell line, HT-29, to test the effects and cellular biological mechanism of nm23 protein in colon cancer. We found that nm23-H1 strongly inhibited the liver metastasis of HT-29 cells in nude mice and inhibited the epidermal growth factor (EGF)-induced cell migration in vitro. Furthermore, we clarified the regulation of the myosin light chain (MLC) phosphorylation by nm23-H1, which has been demonstrated as having potential role in cell migration.
| Original language | English |
|---|---|
| Pages (from-to) | 207-211 |
| Number of pages | 5 |
| Journal | International Journal of Cancer |
| Volume | 108 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 10 2004 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Colon cancer cell
- MAPK
- Migration
- Myosin light chain
- nm23-H1
ASJC Scopus subject areas
- Oncology
- Cancer Research
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