Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review

Wataru Kitamura; Daisuke Ennishi; Ryoya Yukawa; Ryo Sasaki; Chikamasa Yoshida; Hiroki Takasuka; Hideaki Fujiwara; Noboru Asada; Hisakazu Nishimori; Keiko Fujii; Nobuharu Fujii; Ken Ichi Matsuoka; Koji Abe; Tadashi Yoshino; Yoshinobu Maeda

doi:10.2169/internalmedicine.7180-21

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review

Wataru Kitamura, Daisuke Ennishi, Ryoya Yukawa, Ryo Sasaki, Chikamasa Yoshida, Hiroki Takasuka, Hideaki Fujiwara, Noboru Asada, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Ken Ichi Matsuoka, Koji Abe, Tadashi Yoshino, Yoshinobu Maeda

Research output: Contribution to journal › Review article › peer-review

Abstract

A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-piodoamphetamine (¹²³I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

Original language	English
Pages (from-to)	3155-3160
Number of pages	6
Journal	Internal Medicine
Volume	60
Issue number	19
DOIs	https://doi.org/10.2169/internalmedicine.7180-21
Publication status	Published - 2021

Keywords

Chorea
Peripheral T-cell lymphoma
Single photon-emission computed tomography

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.2169/internalmedicine.7180-21

Cite this

Kitamura, W., Ennishi, D., Yukawa, R., Sasaki, R., Yoshida, C., Takasuka, H., Fujiwara, H., Asada, N., Nishimori, H., Fujii, K., Fujii, N., Matsuoka, K. I., Abe, K., Yoshino, T., & Maeda, Y. (2021). Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review. Internal Medicine, 60(19), 3155-3160. https://doi.org/10.2169/internalmedicine.7180-21

Kitamura, W, Ennishi, D, Yukawa, R, Sasaki, R, Yoshida, C, Takasuka, H, Fujiwara, H , Asada, N , Nishimori, H , Fujii, K , Fujii, N , Matsuoka, KI, Abe, K, Yoshino, T & Maeda, Y 2021, 'Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review', Internal Medicine, vol. 60, no. 19, pp. 3155-3160. https://doi.org/10.2169/internalmedicine.7180-21

@article{706a73ef648d4607936a498fce64d26a,

title = "Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review",

abstract = "A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-piodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.",

keywords = "Chorea, Peripheral T-cell lymphoma, Single photon-emission computed tomography",

author = "Wataru Kitamura and Daisuke Ennishi and Ryoya Yukawa and Ryo Sasaki and Chikamasa Yoshida and Hiroki Takasuka and Hideaki Fujiwara and Noboru Asada and Hisakazu Nishimori and Keiko Fujii and Nobuharu Fujii and Matsuoka, {Ken Ichi} and Koji Abe and Tadashi Yoshino and Yoshinobu Maeda",

note = "Publisher Copyright: {\textcopyright} 2021 The Japanese Society of Internal Medicine",

year = "2021",

doi = "10.2169/internalmedicine.7180-21",

language = "English",

volume = "60",

pages = "3155--3160",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "19",

}

TY - JOUR

T1 - Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment

T2 - A Case Report and Literature Review

AU - Kitamura, Wataru

AU - Ennishi, Daisuke

AU - Yukawa, Ryoya

AU - Sasaki, Ryo

AU - Yoshida, Chikamasa

AU - Takasuka, Hiroki

AU - Fujiwara, Hideaki

AU - Asada, Noboru

AU - Nishimori, Hisakazu

AU - Fujii, Keiko

AU - Fujii, Nobuharu

AU - Matsuoka, Ken Ichi

AU - Abe, Koji

AU - Yoshino, Tadashi

AU - Maeda, Yoshinobu

PY - 2021

Y1 - 2021

N2 - A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-piodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

AB - A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-piodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

KW - Chorea

KW - Peripheral T-cell lymphoma

KW - Single photon-emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=85116589587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85116589587&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.7180-21

DO - 10.2169/internalmedicine.7180-21

M3 - Review article

C2 - 33814503

AN - SCOPUS:85116589587

SN - 0918-2918

VL - 60

SP - 3155

EP - 3160

JO - Internal Medicine

JF - Internal Medicine

IS - 19

ER -

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this