Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines

Masaya Kawase; Kohji Yamamoto; Keita Takagi; Ryohei Yasuda; Masafumi Ogawa; Yasutoshi Hatsuda; Sonoyo Kawanishi; Yoshihiko Hirotani; Michiaki Myotoku; Yoko Urashima; Katsuhito Nagai; Kenji Ikeda; Hiroki Konishi; Junji Yamakawa; Masahiko Tani

doi:10.1007/s10762-013-9994-2

Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines

Masaya Kawase, Kohji Yamamoto, Keita Takagi, Ryohei Yasuda, Masafumi Ogawa, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Yoko Urashima, Katsuhito Nagai, Kenji Ikeda, Hiroki Konishi, Junji Yamakawa, Masahiko Tani

School of Science

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

Original language	English
Pages (from-to)	566-571
Number of pages	6
Journal	Journal of Infrared, Millimeter, and Terahertz Waves
Volume	34
Issue number	9
DOIs	https://doi.org/10.1007/s10762-013-9994-2
Publication status	Published - Sept 2013

Keywords

Medical security maintenance
Non-destructive method
Pharmaceutical tablet
Sound-alike medicine
THz-TDS

ASJC Scopus subject areas

Radiation
Instrumentation
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1007/s10762-013-9994-2

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Kawase, M., Yamamoto, K., Takagi, K., Yasuda, R., Ogawa, M., Hatsuda, Y., Kawanishi, S., Hirotani, Y., Myotoku, M., Urashima, Y., Nagai, K., Ikeda, K., Konishi, H., Yamakawa, J., & Tani, M. (2013). Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines. Journal of Infrared, Millimeter, and Terahertz Waves, 34(9), 566-571. https://doi.org/10.1007/s10762-013-9994-2

Kawase, M, Yamamoto, K, Takagi, K, Yasuda, R, Ogawa, M, Hatsuda, Y, Kawanishi, S, Hirotani, Y, Myotoku, M, Urashima, Y, Nagai, K, Ikeda, K, Konishi, H, Yamakawa, J & Tani, M 2013, 'Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines', Journal of Infrared, Millimeter, and Terahertz Waves, vol. 34, no. 9, pp. 566-571. https://doi.org/10.1007/s10762-013-9994-2

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abstract = "To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.",

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author = "Masaya Kawase and Kohji Yamamoto and Keita Takagi and Ryohei Yasuda and Masafumi Ogawa and Yasutoshi Hatsuda and Sonoyo Kawanishi and Yoshihiko Hirotani and Michiaki Myotoku and Yoko Urashima and Katsuhito Nagai and Kenji Ikeda and Hiroki Konishi and Junji Yamakawa and Masahiko Tani",

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doi = "10.1007/s10762-013-9994-2",

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AU - Yamamoto, Kohji

AU - Takagi, Keita

AU - Yasuda, Ryohei

AU - Ogawa, Masafumi

AU - Hatsuda, Yasutoshi

AU - Kawanishi, Sonoyo

AU - Hirotani, Yoshihiko

AU - Myotoku, Michiaki

AU - Urashima, Yoko

AU - Nagai, Katsuhito

AU - Ikeda, Kenji

AU - Konishi, Hiroki

AU - Yamakawa, Junji

AU - Tani, Masahiko

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N2 - To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

AB - To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

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KW - Non-destructive method

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Non-destructive evaluation method of pharmaceutical tablet by terahertz-time-domain spectroscopy: Application to sound-alike medicines

Abstract

Keywords

ASJC Scopus subject areas

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