Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

Shin Ichiro Kajiyama; Hiroshi Kanzaki; Kazuyoshi Kawazu; Akio Kobayashi

doi:10.1016/S0040-4039(98)00573-5

Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

Shin Ichiro Kajiyama, Hiroshi Kanzaki, Kazuyoshi Kawazu, Akio Kobayashi

School of Agriculture

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel β-amino acid, 3-amino-6-hydroxy stearic acid (Ahs) in its structure.

Original language	English
Pages (from-to)	3737-3740
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(98)00573-5
Publication status	Published - May 28 1998

Keywords

Algae
Amino acid and derivatives
Antifungals
Natural products

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)00573-5

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title = "Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune",

abstract = "In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel β-amino acid, 3-amino-6-hydroxy stearic acid (Ahs) in its structure.",

keywords = "Algae, Amino acid and derivatives, Antifungals, Natural products",

author = "Kajiyama, {Shin Ichiro} and Hiroshi Kanzaki and Kazuyoshi Kawazu and Akio Kobayashi",

note = "Funding Information: We are grateful to Dr. H. Takahashi (Kyowa Hakko co. ltd., Japan) for the cytotoxicity test and to Mr. K. Sasaki (Okayama Univ.) for the antifungal test. We also thank Dr. E. Fukusaki (Osaka Univ.) for helpful discussions. This work was supported in part by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan. (No. 09255105)",

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doi = "10.1016/S0040-4039(98)00573-5",

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T1 - Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

AU - Kajiyama, Shin Ichiro

AU - Kanzaki, Hiroshi

AU - Kawazu, Kazuyoshi

AU - Kobayashi, Akio

N1 - Funding Information: We are grateful to Dr. H. Takahashi (Kyowa Hakko co. ltd., Japan) for the cytotoxicity test and to Mr. K. Sasaki (Okayama Univ.) for the antifungal test. We also thank Dr. E. Fukusaki (Osaka Univ.) for helpful discussions. This work was supported in part by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan. (No. 09255105)

PY - 1998/5/28

Y1 - 1998/5/28

N2 - In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel β-amino acid, 3-amino-6-hydroxy stearic acid (Ahs) in its structure.

AB - In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel β-amino acid, 3-amino-6-hydroxy stearic acid (Ahs) in its structure.

KW - Algae

KW - Amino acid and derivatives

KW - Antifungals

KW - Natural products

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U2 - 10.1016/S0040-4039(98)00573-5

DO - 10.1016/S0040-4039(98)00573-5

M3 - Article

AN - SCOPUS:0032575172

SN - 0040-4039

VL - 39

SP - 3737

EP - 3740

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

Abstract

Keywords

ASJC Scopus subject areas

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