TY - JOUR
T1 - Note Effects of Chlorpromazine and Estradiol Benzoate on Prolactin Secretion in Gonadectomized Male and Female Rats
AU - Takahashi, Sumio
AU - Kawashima, Seiichiro
AU - Wakabayashi, Katsumi
PY - 1979
Y1 - 1979
N2 - Synopsis The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5 µg EB 48 hr before CPZ injection abolished this sexual difference in serum PRL concentration.
AB - Synopsis The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25 mg/kg body weight) produced an elevation of PRL when measured 2 hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5 µg EB 48 hr before CPZ injection abolished this sexual difference in serum PRL concentration.
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U2 - 10.1507/endocrj1954.26.419
DO - 10.1507/endocrj1954.26.419
M3 - Article
C2 - 477628
AN - SCOPUS:0018725445
SN - 0918-8959
VL - 26
SP - 419
EP - 422
JO - Endocrine Journal
JF - Endocrine Journal
IS - 3
ER -