Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity

Hiroyuki Miyachi; Akihiko Azuma; Asuka Ogasawara; Eiji Uchimura; Naoko Watanabe; Yoshiro Kobayashi; Fuminori Kato; Masanari Kato; Yuichi Hashimoto

doi:10.1021/jm970109q

Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity

Hiroyuki Miyachi, Akihiko Azuma, Asuka Ogasawara, Eiji Uchimura, Naoko Watanabe, Yoshiro Kobayashi, Fuminori Kato, Masanari Kato, Yuichi Hashimoto

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.

Original language	English
Pages (from-to)	2858-2865
Number of pages	8
Journal	Journal of medicinal chemistry
Volume	40
Issue number	18
DOIs	https://doi.org/10.1021/jm970109q
Publication status	Published - Aug 29 1997

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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abstract = "Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.",

author = "Hiroyuki Miyachi and Akihiko Azuma and Asuka Ogasawara and Eiji Uchimura and Naoko Watanabe and Yoshiro Kobayashi and Fuminori Kato and Masanari Kato and Yuichi Hashimoto",

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T1 - Novel biological response modifiers

T2 - Phthalimides with tumor necrosis factor-α production-regulating activity

AU - Miyachi, Hiroyuki

AU - Azuma, Akihiko

AU - Ogasawara, Asuka

AU - Uchimura, Eiji

AU - Watanabe, Naoko

AU - Kobayashi, Yoshiro

AU - Kato, Fuminori

AU - Kato, Masanari

AU - Hashimoto, Yuichi

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Y1 - 1997/8/29

N2 - Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.

AB - Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3- diones) were prepared, and their effects on tumor necrosis factor-α (TNF- α) production by human leukemia cell line HL-60 stimulated with 12-O- tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N- benzylphthalimides revealed that their enhancing effect on TPA-induced TNF- α production by HL-60 cells and their inhibiting effect on OA-induced TNF- α production by HL-60 cells are only partially correlated.

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Novel biological response modifiers: Phthalimides with tumor necrosis factor-α production-regulating activity

Abstract

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