Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)

Hiroyuki Miyachi, Hiromi Kiyota, Mitsuru Segawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent.

Original languageEnglish
Pages (from-to)1807-1812
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number14
Publication statusPublished - Jul 21 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)'. Together they form a unique fingerprint.

Cite this