Novel taxa-4(20),12-diene and 2(3→20)abeotaxane from needles of Taxus canadensis

Zhi Yu Ni, Yi Bing Wu, Man Li Zhang, Yu Fang Wang, Mei Dong, Françoise Sauriol, Chang Hong Huo, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota, Bin Cong

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A novel 6/8/6-membered taxane with a rare C-12(13)-double bond and rare 2(3→20)abeotaxane were isolated from the needles of Taxus canadensis. Their structures were characterized as 7β,9α,10β-triacetoxytaxa- 4(20),12-diene-2α,5α,11β-triol (1) and 2α,7β, 10β- triacetoxy-5α-hydroxy-2(3→20)abeotaxa-4(20),11-diene- 9,13-dione (2) on the basis of 1D and 2D spectroscopic data. 1 is the first example of a natural taxane without substitution at both C-13 and C-14.

Original languageEnglish
Pages (from-to)1698-1701
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number9
Publication statusPublished - 2011
Externally publishedYes


  • 12-diene
  • Isolation
  • Needle
  • Taxa-4(20)
  • Taxane
  • Taxus canadensis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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