Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

Zhioxiong Wang; Yoshiaki Itoh; Yoshifumi Hosaka; Ichiro Kobayashi; Yoshihisa Nakano; Isamu Maeda; Fusako Umeda; Junji Yamakawa; Masaya Kawase; Kiyohito Yagi

doi:10.1263/jbb.95.541

Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

Zhioxiong Wang, Yoshiaki Itoh, Yoshifumi Hosaka, Ichiro Kobayashi, Yoshihisa Nakano, Isamu Maeda, Fusako Umeda, Junji Yamakawa, Masaya Kawase, Kiyohito Yagi

School of Science

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

Original language	English
Pages (from-to)	541-543
Number of pages	3
Journal	Journal of Bioscience and Bioengineering
Volume	95
Issue number	5
DOIs	https://doi.org/10.1263/jbb.95.541
Publication status	Published - Jan 1 2003

Keywords

Dendrimer
Polyhydroxyalkanoate
Tamsulosin
Transdermal drug delivery system

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

Access to Document

10.1263/jbb.95.541

Cite this

@article{51cdc3a8856a4c849e91117ff6c6b048,

title = "Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer",

abstract = "In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.",

keywords = "Dendrimer, Polyhydroxyalkanoate, Tamsulosin, Transdermal drug delivery system",

author = "Zhioxiong Wang and Yoshiaki Itoh and Yoshifumi Hosaka and Ichiro Kobayashi and Yoshihisa Nakano and Isamu Maeda and Fusako Umeda and Junji Yamakawa and Masaya Kawase and Kiyohito Yagi",

year = "2003",

month = jan,

day = "1",

doi = "10.1263/jbb.95.541",

language = "English",

volume = "95",

pages = "541--543",

journal = "Journal of Bioscience and Bioengineering",

issn = "1389-1723",

publisher = "The Society for Biotechnology, Japan",

number = "5",

}

TY - JOUR

T1 - Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

AU - Wang, Zhioxiong

AU - Itoh, Yoshiaki

AU - Hosaka, Yoshifumi

AU - Kobayashi, Ichiro

AU - Nakano, Yoshihisa

AU - Maeda, Isamu

AU - Umeda, Fusako

AU - Yamakawa, Junji

AU - Kawase, Masaya

AU - Yagi, Kiyohito

PY - 2003/1/1

Y1 - 2003/1/1

N2 - In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

AB - In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.

KW - Dendrimer

KW - Polyhydroxyalkanoate

KW - Tamsulosin

KW - Transdermal drug delivery system

UR - http://www.scopus.com/inward/record.url?scp=0038509152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038509152&partnerID=8YFLogxK

U2 - 10.1263/jbb.95.541

DO - 10.1263/jbb.95.541

M3 - Article

C2 - 16233454

AN - SCOPUS:0038509152

SN - 1389-1723

VL - 95

SP - 541

EP - 543

JO - Journal of Bioscience and Bioengineering

JF - Journal of Bioscience and Bioengineering

IS - 5

ER -

Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this