@article{f2c5ca40e793477a95ab9c5965fc0320,
title = "Nuclear magnetic resonance study of Gd-based nanoparticles to tag boron compounds in boron neutron capture therapy",
abstract = "We report the investigation of new organic complexes containing a magnetic moment (Gd-based molecular nanomagnets), which can serve the double purpose of acting as boron neutron capture therapy (BNCT) agents, and at the same time act as contrast agents to detect the molecule in the tissue by a proton magnetic resonance imaging (MRI). We also explore the possibility of monitoring the concentration of the BNCT agent directly via proton and boron NMR relaxation. The absorption of 10B-enriched molecules inside tumoral liver tissues has been shown by NMR measurements and confirmed by spectroscopy. A new molecular Gd-tagged nanomagnet and BNCT agent (GdBPA) has been synthesized and characterized measuring its relaxivity R1 between 10 kHz and 66 MHz, and its use as a contrast agent in MRI has been demonstrated. The NMR-based evidence of the absorption of GdBPA into living tumoral cells is also shown.",
author = "M. Corti and M. Bonora and F. Borsa and S. Bortolussi and N. Protti and D. Santoro and S. Stella and S. Altieri and C. Zonta and Clerici, {A. M.} and L. Cansolino and C. Ferrari and P. Dionigi and A. Porta and G. Zanoni and G. Vidari",
note = "Funding Information: This research has been supported by Fondazione Cariplo, Bando 2008 “Ricerca Scientifica e Tecnologica sui Materiali Avanzati,” Progetto 2227. We thank Professor Alessandro Lascialfari and Dr. Paolo Arosio for the assistance in the fast field cycling relaxometry measurements. FIG. 1. Charged particles spectrum of a BPA-treated rat liver sample. The gray area is correlated to the 10 B tissue concentration. FIG. 2. NMR echo-detected saturation recovery profiles for GdBPA-treated cells (T 1 = 200 ms) and for reference cells (T 1 = 1100 ms) are shown. In the inset, a cartoon of the newly synthesized GdBPA molecule is depicted. FIG. 3. T 1 -weighted MRI image for pure water (1), GdBPA 0.02 mM in water (2), and GdBPA 0.08 mM in water (3). The image contrast effect of GdBPA is clearly visible. ",
year = "2011",
month = apr,
day = "1",
doi = "10.1063/1.3556951",
language = "English",
volume = "109",
journal = "Journal of Applied Physics",
issn = "0021-8979",
publisher = "American Institute of Physics Publising LLC",
number = "7",
}